Articles and white papers
On this page we offer our white papers and articles for download.
Comparison of Phase I/II trials regarding antigen-specific versus non-specific anticancer immunotherapies
10 May 2016, Julia Holland, Renata Zwerver, Nadina Grosios and Raymond Hoffmans
Antigen-specific immunotherapy targets particular tumour associated antigens in order to address and eradicate solely tumour-marker defined cancer cells. In contrast, non-specific agents generally stimulate the immune system by for examp...Read more
Comparison of study designs, objectives and results of Phase I trials with cytotoxic versus non-cytotoxic anticancer agents
2 March 2015, Lindy Bosch, Edwin Klumper and Raymond Hoffmans
Cytotoxic anticancer agents are designed to kill tumor cells by interfering with cell division mechanisms. In contrast, non-cytotoxic anticancer agents intend to inhibit cancer growth by targeting specific proteins or signaling pathways...Read more
Put to the Test
5 January 2015, Lindy Bosch and Raymond Hoffmans
Typical Phase 1 oncology studies have changed and evolved as new techniques have developed, and target therapies have begun to reach the market. By looking at the types of drugs used, the dose levels tested and the patient populations fo...Read more
Personalised Medicine in Cancer Treatment: Hype or Hope?
1 January 2012, Edwin Klumper
Cure rates in cancer are improving steadily but slowly. Early diagnosis and removal of the primary tumour remain the cornerstone of cures. The efficacy of systemic treatment in advanced disease is modest, despite the discovery of many ne...Read more